Endocrine Abstracts

Introduction: Parathyroid adenoma is the most common cause of primary hyperparathyroidism. Effective preoperative imaging and localizing the parathyroid adenoma is a prerequisite for the surgical treatment. 99mTc-MIBI scintigraphy in combination with ultrasound of the neck are the imaging modalities of choice before parathyroidectomy. However, both have limitations in terms of their efficacy in localizing the adenomas; 11C-Methionine or 18F-Fluorocholine PET/CT has ...

Introduction: We present a rare case of 49-year-old patient with neurofibromatosis type I and somatostatin-secreting pancreatic neuroendocrine neoplasm. World literature describes about 30 cases of duodenal somatostatinoma in NFI1 and 1/3 of these cases with metastases to the lymph nodes or liver.Case report: In October 2013 patient was operated in emergency due to gastrointestinal tract obstruction. During the procedure inoperable head of pancreas tumou...

Objective: To determine the percentage of patients with acromegaly who received lanreotide Autogel 120 mg (ATG120) in extended duration interval and to evaluate the mean costs of ATG120 administered as part of routine care in Poland.Methods: National, multicentre, non-interventional, observational prospective study with 2-years’ time horizon. The study population consisted of adult acromegaly patients who received at least three injections of ATG120...

Objective: The aim of the study was to examine characteristics and treatment patterns of Polish acromegalic patients.Methods: A retrospective database analysis was conducted. Adult acromegalic patients treated medically for ≥1 year including at least three injections of lanreotide AUTOGEL 120 were recruited in 36 centres between 29/10/2010 and 31/03/2012. Descriptive analysis was performed to describe demographic and clinical characteristics, treat...

Background: The NETest, a neuroendocrine multigene transcript ‘liquid biopsy’, is a novel biomarker for GEP-NETs. Current biomarkers are monoanalyte amines or peptides whereas the NETest is a multianalyte signature providing molecular biological information pertinent to clinical disease.Aim: Independently validate the utility of the NETest for the diagnosis of GEP-NETs and identification of disease progression.Material an...

Adiponectin (ADPN), resistin (RSN) and leptin are proteins that affect insulin resistance and atherosclerosis significantly. Although low levels of adiponectin and high levels of resistin and leptin are associated with coronary heart disease and cardiovascular disease risk factors, it is unclear whether adiponectin, resistin and leptin levels are related to the risk of developing ischemic stroke. The aim of the study was to evaluate the adiponectin, resistin and leptin serum l...

Introduction: Hipersecretion of somatotrophin axis hormones in acromegaly favours the development of numerous metabolic and organ complications. The aim of the study was to establish the occurrence integrity of these complications in acromegalics.Material and methods: The tested 72 acromegalics – 32 men aged 46.9±15.2 years and 40 women aged 58.8±12.0 years, for which the period of the illness was determined, the body mass index (BMI) and ...

Introduction: Urgent conditions, as first symptom of endocrine disease, are rather rare in a hospital emergency department. Emergency medicine doctors work in difficult conditions, often under time pressure, they must also be guided by the likelihood of linking symptoms to the disease. Unfortunately, this makes it difficult to diagnose rare diseases. Therefore, without criticising doctors of other specialties, we would like to present our patient’s long journey from the e...

Autoimmune thyroiditis (AIT) is characterised by infiltration of the thyroid by lymphocytes and other immune cells. Autoantibodies to thyroid-specific antigens: thyroglobulin (TG) and thyroperoxidase (TPO) are also produced. The penetration of inflammatory cells into target organ is regulated by cytokines and adhesion molecules expressed on thyroid endothelial cells. E-selectin is one of the selectin family, and is responsible for interaction between leukocytes and endothelium...

Background: There are no effective blood biomarkers for bronchopulmonary carcinoids (BPC). We examined the utility of a neuroendocrine multigene transcript ‘liquid biopsy’ (NETest) in bronchopulmonary carcinoids (BPC) for diagnosis and monitoring of disease status.Aim: To independently validate the utility of the NETest in diagnosis and management of BPC in a prospective multicenter, multinational blinded study.Material a...